Limfoma Burkitt

Limfoma Burkitt. Burkitt lymphoma (BL) is a highly aggressive Bcell nonHodgkin lymphoma categorized into endemic sporadic and immunodeficiencyassociated subtypes BL has distinct pathologic and clinical features characterized by rapidly progressive tumors with high rates of extranodal involvement Nextgener Author Jennifer Crombie Ann LaCasceCited by Publish Year 2021.

TypesStagesCauses and Risk FactorsTreatmentPrognosisCopingThere are two broad types of Burkitt’s lymphoma—the sporadic and the endemic varieties There is a very high incidence of this disease in equatorial Africa2 and disease in this region is called endemic Burkitt’s lymphoma Disease in other regions of the world is much less common and is called sporadic Burkitt’s lymphoma1 Though they are the same disease the two forms are different in many ways This disease can be broken down simplistically into four separate stages (note this is not complete and there may be overlap in some cases) Stage I Stage I disease means that the cancer is present at only one site in the body Stage II Stage II Burkitt&#39s lymphomas are present in more than one site but both sites are on one side of the diaphragm Stage III Stage III disease is present in lymph nodes or other sites on both sides of the diaphragm Stage IV Stage IV disease includes lymphomas which are found in the bone marrow or in the brain (central nervous system) As noted above EpsteinBarr is associated with the majority of cases of endemic Burkitt&#39s lymphoma as well as some cases of sporadic disease Being immunosuppressed is a risk factor6 and in Africa it&#39s thought that malaria may set children up to be more vulnerable to the EpsteinBarr virus7 Burkitt’s lymphoma is a highly aggressive tumor and often lifethreatening But it is also one of the more curable forms of lymphoma To understand this it helps to understand that chemotherapy attacks the most rapidly dividing cells The ability to use chemotherapy has made some of the most aggressive lymphoma and leukemias of the past the most treatable and potentially curable at the present time With current aggressive forms of chemotherapy that use drugs in high doses and with the availability of new measures to support individuals during intensive treatment this lymphoma is curable in many patients The prognosis for Burkitt&#39s lymphoma in the United States has markedly improved in recent years Between 2002 and 2008 the 5year survival rate went from 71 to 87 percent in children between birth and 19 years of age For those aged 20 to 39 the survival rate improved from 35 to 60 percent and for patients older than 40 the survival rate improved as well8 Since that time further improvements in treatments as well as management of side effects have taken place It can be terrifying to be diagnosed with lymphoma and even worse if it is your child who is diagnosed Raising a child takes a village to begin with but you will need your support system more than ever in this case Reach out to others This tumor is fairly rare but via social media there is an active online community of people coping with this disease that you can get in touch with for support Lymphoma and leukemia organizations can provide further assistance for you along the way Occupation Radiation Oncologist.

Burkitt lymphoma Lymphoma Research Foundation

Burkitt lymphoma is an aggressive Bcell lymphoma comprising a monomorphic population of intermediatesized mature lymphocytes The cells contain round nuclei with lacy chromatin and may have one or more small nucleoli The cells characteristically have basophilic cytoplasm with prominent vacuoles On hematoxylineosin (HandE) stained sections the cells have distinct cytoplasmic borders giving them a molded appearance.

Burkitt lymphoma Genetic and Rare Diseases Information

Clinical significanceEpidemiologyCausesTranslocation (a type of rearrangement) of a gene called MYC is a hallmark of Burkitt lymphoma making this an important finding for diagnosis In adults Burkitt lymphoma is often indistinguishable from diffuse large Bcell lymphoma (DLBCL)another aggressive Bcell lymphoma Accurate diagnosis of Burkitt lymphoma is critical because Burkitt lymphoma and DLBCL are treated differently That is why it is strongly recommended patients seek an opinion from an expert in lymphoma Endemic Burkitt lymphoma originates in Africa It is the most common type of Burkitt lymphoma and the most common childhood cancer overall It has an incidence rate of about 50 times higher in equatorial Africa and New Guinea than in the US The most common site of endemic disease is the jaw EpsteinBarr virus (EBV) has been shown to be linked to the endemic form of Burkitt lymphoma Sporadic Burkitt lymphoma occurs throughout the world This form seen in the United States and Western Europe accounts for less than one percent of Bcell NHLs in adults however it accounts for 30 percent of all childhood lymphomas An abdominal tumor is the most common site of disease occurrence Immunodeficiencyrelated variety of Burkitt lymphoma is most common in people with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) It can also occur in patients who have inherited immune deficiencies or those who take immunosuppressive medications to prevent rejection after an organ transplant.

Types, Treatment, and Prognosis of Burkitt Lymphoma

Burkitt&#39s lymphoma is the most common childhood cancer in areas where malaria is holoendemic The incidence is very high in immunosuppressed patients in nonendemic areas especially when associated with HIV infection Author Elizabeth M Molyneux Rosemary Rochford Beverly Griffin Robert Newton Graham Jackson Geetha MenoCited by Publish Year 2012.